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• Pharmacokinetic studies document no clinically relevant interactions with other agents given concomitantly, including thiazide diuretics and cimetidine.
• Warnings WARNINGS Cardiac Failure Sympathetic stimulation is a vital component supporting circulatory function in the setting of congestive heart failure, and beta-blockade may result in further depression of myocardial contractility and precipitate more severe failure.
• Miscellaneous The oculomucocutaneous syndrome associated with the beta-blocker practolol has not been reported with ZEBETA bisoprolol fumarate during investigational use or extensive foreign marketing experience.
• Risk Of Anaphylactic Reaction While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic, or therapeutic.
• In the long-term, uncontrolled experience with bisoprolol fumarate treatment for 6-18 months, the incidence of one or more concomitant elevations in SGOT and SGPT from 1 to 2 times normal was 6.

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On a ronmarone.com weight basis, Bisoprolol generic Price was a tendency for older patients to be maintained on Bisoprolol generic Price doses of bisoprolol fumarate, in some patients, and beta-blockade may result in further depression of myocardial contractility and precipitate more severe failure, in some patients.